We have been using Cascading Style sheets level 2.1 for some time now for basic layout, and relying on photoshop artist to create the backgrounds.

For example on this site this box has curved corners and multiple shadows. Typically you would need Photoshop for things like this, but not any more. Providing youd don't overdo it, CSS level 3 can make things look pretty nice without a trip to the designer.

Try resizing the page and you will see all the adaptive layout is pure CSS.

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css3 box shadows

Some of the coolest website effects I have seen come from CSS shadows. Namely the box shadow which in itself if cool, but when combined with other box shadows suddely becomes very cool.